Research Interests

Josh’s primary research interests focus on using artificial intelligence to reduce inapprorpriate antibiotic use. This “precision antimicrobial stewardship” leverages newer analytical techniques such as machine learning and natural language processing to improve the quality of antimicrobial stewardship-related analyses and subsequent interventions. Josh also has interests in patient safety, health care quality improvement, and health disparities.

Publications

Wirtz AL, Burns AN, Monsees E, Lee BR, Herigon JC. Development and implementation of the Antimicrobial Stewardship Intervention Scoring Tool at a single pediatric institution. Infect Control Hosp Epidemiol. 2024 Sep 16:1–6. doi: 10.1017/ice.2024.114. PMID: 39279733.

Wirtz AL, Metjian TA, Parker SK, Herigon JC, MacBrayne CE. At the break point: What needs to change for antimicrobial stewardship program pharmacists? Am J Health Syst Pharm. 2024 Jul 3:zxae175. doi: 10.1093/ajhp/zxae175. PMID: 38957935.

Herigon JC, El Feghaly RE. “Oral is the new IV”…from the start. J Hosp Med. 2024 Jun 2. doi: 10.1002/jhm.13428. PMID: 38824492.

Vernacchio L, Hatoun J, Patane LB, O’Donnell H, Herigon JC. Improving Short Course Treatment of Pediatric Infections: A Randomized Quality Improvement Trial. Pediatrics. 2024 Jan 1;153(2):e2023063691. doi: 10.1542/peds.2023–063691. PMID: 38168832.

Poole NM, Lee BR, Kronman MP, Smith MJ, Patel SJ, Olivero R, Wattles BA, Herigon JC, Wirtz A, El Feghaly RE. Ambulatory amoxicillin use for common acute respiratory infections during a national shortage: Results from the SHARPS-OP benchmarking collaborative. Am J Infect Control. 2023 Dec 27:S0196–6553(23)00875–1. doi: 10.1016/j.ajic.2023.12.014. PMID: 38158158.

Swords KE, Weddle GM, Herigon JC, Stering PD, Lee MSL. One size does not fit all: advanced practice provider considerations for the antimicrobial steward. Antimicrob Steward Healthc Epidemiol. 2023 Aug 18;3(1):e139. doi: 10.1017/ash.2023.199. PMID: 37663451; PMCID: PMC10468717.

Baker AH, Leland SB, Freiman E, Herigon JC, Eisenberg MA. Characteristics and Outcomes of Culture-Positive and Culture-Negative Pediatric Sepsis. J Pediatr. 2023 Dec;263:113718. PMID: 37659590.

El Feghaly RE, Herigon JC, Kronman MP, Wattles BA, Poole NM, Smith MJ, Vaughan AM, Olivero R, Patel SJ, Wirtz A, Willis Z, Lee BR. Benchmarking of Outpatient Pediatric Antibiotic Prescribing: Results of a Multicenter Collaborative. J Pediatric Infect Dis Soc. 2023 Jun 1:piad039. doi: 10.1093/jpids/piad039. PMID: 37262431.

Vernacchio L, Herigon JC, Hatoun J, Patane LB, Correa ET. The Antibiotic Likelihood Index: A New Measure of Antimicrobial Stewardship for Pediatric Primary Care Based on Reason for Visit. J Pediatric Infect Dis Soc. 2021 Dec 18:piab110. doi: 10.1093/jpids/piab110. Epub ahead of print. PMID: 34922373.

Byler S, Baker A, Freiman E, Herigon JC, Eisenberg MA. Utility of specific laboratory biomarkers to predict severe sepsis in pediatric patients with SIRS. Am J Emerg Med. 2021 Dec;50:778–783. doi: 10.1016/j.ajem.2021.09.081. Epub 2021 Oct 6. PMID: 34879502.

Hong P, Herigon JC, Uptegraft C, Samuel B, Brown DL, Bickel J, Hron JD. Use of clinical data to augment healthcare worker contact tracing during the COVID–19 pandemic. J Am Med Inform Assoc. 2021 Oct 8:ocab231. doi: 10.1093/jamia/ocab231. PMID: 34623426.

Ferguson RA, Herigon JC, Lee BR, Nakamura MM, Newland JG. Variability in Ceftriaxone Dosing Across 32 US Acute Care Children’s Hospitals. J Pediatric Infect Dis Soc. 2021 Feb 2:piab004. PMID: 33528009.

Lee RA, Herigon JC, Benedetti A, Pollock NR, Denkinger CM. Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV–2 Molecular Detection: A Systematic Review and Meta-analysis. J Clin Microbiol. 2021 Jan 27:JCM.02881–20. PMID: 33504593.

McCulloh RJ, Fouquet SD, Herigon J, Biondi EA, Kennedy B, Kerns E, DePorre A, Markham JL, Chan YR, Nelson K, Newland JG. Development and implementation of a mobile device-based pediatric electronic decision support tool as part of a national practice standardization project. J Am Med Inform Assoc. 2018; 25(9): 1175–1182. PMID: 29889255

Pahud B, Clark S, Herigon JC, Sherman A, Lynch DA, Hoffman A, Jackson MA. “A pilot program to improve vaccination status for hospitalized children.” Hospital Pediatrics. 2015; 5(1): 35–41. PMID: 25554757

Hersh AL, Lee BR, Hedican EB, Herigon JC, Newland JG. “Linezolid use in hospitalized children.” Pediatric Infectious Disease Journal. 2014; 33(1): e14-e18. PMID: 24352192

Ogden RK, Hedican EB, Stach LM, Herigon JC, Jackson MA, Newland JG. “Antibiotic management of animal bites in children during the methicillin-resistant Staphylococcus aureus era.” Journal of the Pediatric Infectious Diseases Society. 2013; 2(4): 379–381. PMID: 26619500

Goldman JL, Jackson MA, Herigon JC, Hersh AL, Shapiro DJ, Leeder JS. “Trends in adverse reactions to trimethoprim-sulfamethoxazole.” Pediatrics. 2013; 131(1): e103–108. PMID: 23209098

Stach LM, Hedican EB, Herigon JC, Jackson MA, Newland JG. “Clinicians attitudes towards an antimicrobial stewardship program at a children’s hospital.” Journal of the Pediatric Infectious Diseases Society. 2012; 1(3): 190–197. PMID: 26619407

Newland JG, Stach LM, De Lurgio SA, Hedican EB, Yu DL, Herigon JC, Prasad PA, Jackson MA, Myers AL, Zaoutis TE. “Impact of prospective-audit-with-feedback antimicrobial stewardship program at a children’s hospital.” Journal of the Pediatric Infectious Diseases Society. 2012; 1(3): 179–186. PMID: 26619405

Newman RE, Hedican EB, Herigon JC, Williams DD, Williams AR, Newland JG. “Impact of a guideline on management of children hospitalized with community-acquired pneumonia.” Pediatrics. 2012; 129(3): e597–604. PMID: 22351891

Herigon JC, Newland JG. “The role of intention-to-treat analyses in randomized trials.” Infection Control and Hospital Epidemiology. 2012; 33(2): 207–208. PMID: 22227995

Hersh AL, Herigon JC, Ampofo K, Pavia AT, Newland JG. “Rapid increase in use of antiviral therapy for hospitalized children with influenza during the 2009 H1N1 epidemic.” Pediatric Infectious Disease Journal. 2011; 30(10): 895–897. PMID: 21587093

Newland JG, Herigon JC. “Antibiotics provide no additional short-term benefit to surgical management of paediatric skin abscesses.” Evidence Based Medicine. 2010; 15(5): 138–139. PMID: 20643760

Herigon JC, Hersh AL, Gerber JS, Zaoutis TE, Newland JG. “Antibiotic management of Staphylococcus aureus infections at US children’s hospitals, 1999—2008.” Pediatrics. 2010; 125(6): e1294-e1300. PMID: 20478934

Select Oral Presentations

Herigon JC. “Technological Tools for Antimicrobial Stewardship.” ASM/ESCMID Joint Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance. Boston, MA—Sep 19–22, 2023.

Herigon JC. “MyCare App & A Clinician’s Framework for Developing with FHIR.” HL7 FHIR DevDays International. Cleveland, OH—Jun 6, 2022

Wirtz AL, Herigon JC. “Inpatient Pediatric ASP Metrics: Current State and Discussion of a Novel Impact Score.” International Pediatric Antimicrobial Stewardship Conference. St Louis, MO—Jun 2, 2022.

Herigon JC, Hong P. “Hospital-based Digital Contact Tracing for Covid–19.” Harvard Clinical Informatics Lecture Series. Boston, MA—Jan 26, 2021.

Herigon JC, Uptegraft C. “FHIR Starter: Building your first SMART on FHIR app.” American Medical Informatics Association’s Clinical Informatics Conference. Seattle, WA (virtual conference)—May 19–21, 2020. Conference workshop.

Vernacchio L, Correa E, Roomian T, Herigon JC, Hatoun J. “The Antibiotic Likelihood Index: A new measure of antimicrobial stewardship in pediatric primary care.” Pediatric Academic Societies’ Annual Meeting. Presented virtually during summer seminar series—Aug 7, 2020.

Herigon JC, Dukes L. “MedTimeLine: a SMART on FHIR app for infectious diseases consultations.” American Medical Informatics Association’s Annual Symposium. Washington DC—Nov 16–20, 2019. AMIA/HL7 FHIR® Applications Showcase 3rd place winner.

Herigon JC, Roomian T, Hatoun J, Vernacchio L. “Variability in antibiotic prescribing across a state-wide pediatric independent-practice association.” Pediatric Academic Societies’ Annual Meeting. Baltimore, MD—Apr 29-May 6, 2019. Platform presentation.

Herigon JC, Hersh AL, Gerber JS, Zaoutis TE, Newland JG. “Significant changes in antibiotic management of Staphylococcus aureus infections in US Children’s Hospitals from 1999–2008.” Pediatric Academic Societies’ Annual Meeting. Baltimore, MD—May 2–5, 2009. Late breaker platform presentation.